Determination of Effect site targets for Sevoflurane

The equivalent of 10% of the population will undergo anaesthesia in any year.  In Christchurch this translates to about 40,000 anaesthetics per year, and nationally 400,000.  The majority of anaesthetics are based around inhalational or volatile agents. Anaesthetic requirements change considerably and rapidly at different stages of a surgical procedure. By improving the dosing of these drugs through research, there is enormous potential to both improve patient outcome and to achieve significant cost savings.