Function of soluble CD83 in Chronic Lymphocytic Leukaemia

Status: Complete
Year: 2007
Funded: $14,378
Grant Type: Major Project Grant

Soluble CD83 is a potent inhibitor of immune responses, and animal studies have shown that its presence can increase tumour progression. Although levels of sCD83 are elevated in the blood of CLL patients, it has not been established whether CLL cells can release sCD83 and, if they do, whether it represents a mechanism by which they can escape immune surveillance. Understanding how CLL cells escape the immune system is critical for both the development of new therapies, and improving existing approaches such as allogeneic transplantation. The aim of this research is to (i) Identify the optimal stimuli for inducing sCD83 release by CLL cells (ii) Determine the functional significance of sCD83 release by CLL cells (iii) Determine the exact level of CD83 expression by CLL cells before and after activation

Researcher // Dr Judith McKenzie – University of Otago

Dr McKenzie is the Haematology Research Group Leader at the University of Otago, Christchurch.

More About Dr Judith McKenzie

Stay in touch with CMRF

// Get all the latest news and insights to your inbox