The effects of resveratrol’s derivatives on VEGF, IL-6, IL-8 and NF-kB in ovarian cancer in vitro and in vivo studies

Support this project
Status: In-progress
Funded: $62,299
Grant Type: Major Project Grant

Women with advanced ovarian cancer normally have a poor outcome because the tumour has spread within the abdominal cavity at the time of diagnosis. Most women with advanced disease show the sign of building up ofbody fluid; this becomes a clinical challenge for the current treatment management.

Treatments currently available can prolong time of survival, but tumours become resistant to treatment and a cure is rare. In order to prolong time of patient survival, a new form of anti-cancer drugs, showing less side effects and being low cost, is urgently needed. Resveratrol is a food compound and has been found to show anti-tumour activity in a laboratory. But its anti tumour activities are uncertain in humans because resveratrol is highly metabolized and rapidly secreted from the body.

Therefore, compounds that are structurally related to resveratrol may be useful to investigate their anti-tumour activities in human. We are very interested in derivatives of resveratrol and we want to investigate if these derivatives can exhibit anti-cancer activities in a laboratory before we could use them in humans.

Researcher // Dr Kenny Chitcholtan – University of Otago

Dr Chitcholtan research interests are focusing on the activity of tyrosine kinases, targeted inhibitors, effects of ascitic fluid, and anti-tumour properties of natural food compounds in the progression of advanced ovarian cancer.

More About Dr Kenny Chitcholtan

What is Ovarian Cancer?

Ovarian cancer is the name given to cancer affecting the ovaries. It is one of the most common types of cancer in women over the age of 50. If you have ongoing abdominal or back pain, abnormal vaginal bleeding, nausea or bloating, see your doctor for a check up. A screening test for ovarian cancer is only offered to women who have a family history of ovarian cancer or carry a genetic abnormality called BRCA1 or BRCA2. This is because the risk of ovarian cancer is so much higher for these women. Treatment for ovarian cancer will depend on the type of cancer you have and the stage it is at. Treatment may involve a combination of surgery to remove as much of the cancer as possible and chemotherapy to kill the cancerous cells.

Stay in touch with CMRF

// Get all the latest news and insights to your inbox