Immune cell function is known to be affected by vitamin C (ascorbate), and our recent work shows low ascorbate concentrations in cancer patients. We will measure ascorbate content and epigenetic status in circulating immune cells of melanoma patients receiving immunotherapy, and explore the association to treatment outcomes.
This study aims to provide pilot information on the relationship between ascorbate content of immune cells with cellular epigenetic status (level of 5-hydroxy-methyl-citosine (5-hmC)) and response to immunotherapy in patients with metastatic melanoma.
Professor Gabi Dachs completed her undergraduate and PhD studies in Cape Town, South Africa, followed by postdoctoral work at the MRC Harwell in the United Kingdom. Prior to joining the University of Otago in Christchurch, Professor Dachs worked as a senior scientist at the Gray Cancer Institute in London, UK.
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