In the short/medium-term gout causes pain, suffering and time off work and in the long term it can cause bone and joint destruction. read more
A Phenotyping Cocktail Study to Assess Cytochrome P450 Function in Patients with Severe Chronic Obstructive Pulmonary DiseaseSupport this project
Most medicines are removed from our bodies by metabolism. The rate of metabolism of a medicine affects the dose, but can be altered by other medicines, genetics or diseases. Therefore understanding how diseases affect metabolism is important in selecting doses of medicines.
This is one reason some people have side effects from the same dose of a medicine other people manage well. These side-effects are a major cause of hospital admissions. Chronic obstructive pulmonary disease (COPD) is a severe lung disease affecting up to 15% of New Zealanders, and the fourth leading cause of death in New Zealand. It is not known if, or how much, COPD affects drug metabolism.
This study will examine the effect of COPD on drug metabolism. This is important because people with COPD may be treated for other conditions with almost any medicine. Understanding the effects of COPD on drug metabolism could inform better dosing guidelines for patients with COPD. More accurate dosing can make treatments more effective and reduce side effects. With over 200,000 New Zealanders living with COPD, even small improvements will make a big difference.