We have discovered that chlorine bleach produced by white blood cells can modify an important regulatory protein in the immune system called macrophage migrati... read more
Can oxidative stress modify the human epigenome?
This research focuses on changes that occur during infection and inflammation, and will investigate whether oxidative stress generated by immune cells can change the pattern of chemical modifications that are added onto the DNA of human cells (the methylome).
This process is an important regulator of gene activity and acts at the interface between the environment and gene regulation (epigenetics). Epigenetic mechanisms can modulate health and disease development, and therefore, understanding processes, such as methylation of genomic DNA is crucial for understanding how health and disease states are related to environmental interactions.
Dr Stevens is investigating whether nutritional supplementation with micronutrients can influence patterns of DNA methylation in the human genome.More About Dr Aaron Stevens